In accordance with a letter entered into the State Register of Medicines, the Ministry of Health of the Russian Federation has given recommendations to manufacturers of medicines with the active substance ibuprofen to change the instructions for this medicine and add information on new side effects and risks of development of certain diseases that occur when taking such medicines. It states that.

In sections 4.8 “Undesirable reactions” and 4 “Possible adverse reactions” it is recommended to add information on the risks of severe skin reactions such as erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS syndrome and acute generalized exanthematous pustulosis. In systemic administration of ibuprofen, development of Coneys syndrome is possible.